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Signs and Symptoms

The most common symptom of peptic ulcer disease is burning pain in the upper center of the abdomen (called epigastric pain). Pain often comes and goes, improves after eating, and worsens when the stomach is empty (about 2 or 3 hours after eating). Many patients experience severe pain during the middle of the night.

Other PUD symptoms include the following:

Heartburn (acid reflux)
Indigestion (dyspepsia)
Nausea and vomiting
Non-cardiac chest pain
Weight loss
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